Gene variant reduces cholesterol by two mechanisms
High levels of low-density lipoprotein (LDL) cholesterol increases the risk for coronary heart disease.
View ArticlePlvap/PV1 critical to formation of the diaphragms in endothelial cells
Dartmouth scientists have demonstrated the importance of the gene Plvap and the structures it forms in mammalian physiology in a study published in December by the journal Developmental Cell.
View ArticleBlood protein able to detect higher risk of cardiovascular events
Higher levels of pregnancy-associated plasma protein A (PAPP-A) were associated with an increased risk of cardiovascular events in people with cardiac chest pain that developed as a result of heart...
View ArticleA protein enables cardiovascular risk assessment
Researchers at the Charité – Universitätsmedizin Berlin have managed to predict the probability of a cardiovascular patient suffering a heart attack, stroke or arterial occlusion within three months....
View ArticleHaemodialysis works for reducing dabigatran levels: Implications for urgent...
Dabigatran is one of the new oral anticoagulants which are increasingly used to prevent thrombosis. In case of an emergency (e.g. bleeding or urgent surgery), there are - despite the lack of a specific...
View ArticleDiscovery of novel medicine for treatment of chronic wounds
Every 20 seconds, a limb is lost as a consequence of diabetic foot ulcer that does not heal. To date, medical solutions that can change this situation are very limited. In his doctoral thesis Yue Shen...
View ArticleRuconest approved for rare genetic disease
(HealthDay)—Ruconest has been approved by the U.S. Food and Drug Administration to treat hereditary angioedema, a genetic disease that leads to sudden and potentially fatal swelling of the hands, feet,...
View ArticlePotential for ALS treatment found in three proteins
Where ALS comes from and how it progresses are mysteries that continue to vex medical science. But recent research at Sweden's KTH Royal Institute of Technology has found three proteins that could shed...
View ArticlePoor recycling of BACE1 enzyme could promote Alzheimer's disease
Sluggish recycling of a protein-slicing enzyme could promote Alzheimer's disease, according to a study published online on November 21 in The Journal of Cell Biology.
View ArticleResearcher develops model to foster new drug development to treat pain and...
Drawing on X-ray crystallography and experimental data, as well as a software suite for predicting and designing protein structures, a UC Davis School of Medicine researcher has developed an algorithm...
View ArticleTowards more effective treatment for multiple myeloma
A new study from SUNY Downstate Medical Center in Brooklyn, New York, shows that MAL3-101, a recently developed inhibitor of the heat shock protein 70 (Hsp70), appears to have potent anti-tumor effects...
View ArticleNotre Dame researchers report fundamental malaria discovery
A team of researchers led by Kasturi Haldar and Souvik Bhattacharjee of the University of Notre Dame's Center for Rare and Neglected Diseases has made a fundamental discovery in understanding how...
View ArticleDGK-alpha helps cancer cells gain traction and mobilize
Metastasizing cancer cells often express integrins that provide better traction. A new study in The Journal of Cell Biology reveals how a lipid-converting enzyme helps the cells mobilize these integrins.
View ArticleAmyloid beta in the brain of individuals with Alzheimer's disease
While there may not be a consensus whether deposition of amyloid beta contributes to Alzheimer's disease or is a consequence of it, there is agreement that something else is promoting the process....
View ArticleCancer biomarkers re-evaluated
(Medical Xpress) -- Researchers from ETH Zurich have developed a procedure to test the clinical benefits of cancer biomarkers. The method could radically shorten the path from the lab to their...
View ArticleChain reaction in the human immune system trapped in crystals
The complement system is part of the innate immune system and is composed of about 40 different proteins that work together to defend the body against disease-causing microorganisms. The complement...
View ArticleKinesin 'chauffeur' helps HIV escape destruction
A study in The Journal of Cell Biology identifies a motor protein that ferries HIV to the plasma membrane, helping the virus escape from macrophages.
View ArticleAlzheimer's disease in mice alleviated promising therapeutic approach for humans
Pathological changes typical of Alzheimer's disease were significantly reduced in mice by blockade of an immune system transmitter. A research team from Charité - Universitätsmedizin Berlin and the...
View ArticleProtein family linked to autism suppresses the development of inhibitory...
Synapse development is promoted by a variety of cell adhesion molecules that connect neurons and organize synaptic proteins. Many of these adhesion molecules are linked to neurodevelopmental disorders;...
View ArticleCombining plasma screening methods better identifies diagnostic and...
For the first time, scientists have combined genomic and proteomic analysis of blood plasma to enhance identification of genetically regulated protein traits. This could be applied to any large...
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